Nov. 10, 2008 — An eight-year study involving about 15,000 male physicians fizzled to appear a benefit for vitamins C and E in preventing heart attacks or strokes.
The unused consider bolsters previous findings from other huge trials appearing no benefit for vitamin E. But it is one of the primary expansive thinks about to examine the affect of vitamin C supplementation on cardiovascular risk.
“We saw no impact for either vitamin E or C in this consider of men with a moo initial chance for cardiovascular infection,” researcher Howard D. Sesso, ScD, of Boston’s Brigham and Women’s Healing center, tells WebMD.
Fair a decade ago, when enrollment for the Physicians’ Health Study II was occurring, much fervor encompassed antioxidants like vitamin C, vitamin E, and beta-carotene.
Thinks about in mice suggested that these cancer prevention agents made a difference ensure against cardiovascular infection by abating the formation of plaque within the supply routes.
But recent ponders analyzing antioxidant supplementation in people have generally been baffling, showing little or no affect on cardiovascular risk.
The unused ponder, published in the Nov. 12 issue of TheJournal of the American Medical Affiliation, is one of the foremost thoroughly outlined trials to ever address the issue.
A total of 14,641 male doctors who were 50 or more seasoned at enrollment took either 500 milligrams of vitamin C and a fake treatment, 400 International Units (IU) of vitamin E and a placebo, both vitamins, or two placebos every other day for an normal of eight a long time.
Amid this time there were 1,245 affirmed major cardiovascular occasions among the ponder participants.
Not one or the other vitamin, nor the combination of the two, was found to have a critical impact on the hazard for heart assault, stroke, or other cardiovascular events.
The analysts conclude that the discoveries provide no back for the utilize of these supplements for the avoidance of cardiovascular infection in middle-aged and elderly men.
Ponders in ladies have moreover shown small or no advantage for vitamin E supplementation.
“There haven’t been as numerous well-designed huge trials of vitamin C so one might argue that the jury may still be out,” Sesso says.
Multivitamins and Heart Hazard
Sesso and colleagues are continuing to take after men in their ponder who are taking a multivitamin supplement.
“This is often the as it were trial that I am mindful of analyzing multivitamin use over more than a decade of follow-up,” he says.
“The predominance of multivitamin use is very tall. Many people, including myself, take them without truly having any hard evidence from long-term, large-scale clinical trials to back claims of benefits.”
Mayo Clinic cardiologist Raymond Gibbons, MD, says patients want to believe that vitamins can secure their hearts indeed though there is little evidence to support this.
Gibbons is a past president of the American Heart Association.
“When I tell my patients there’s no data to bolster the use of vitamins they don’t want to believe me,” he says. “A lot of money has gone into advancing vitamins for heart health, and producers can make very striking claims because vitamins aren’t regulated by the FDA.”
Annette Dickinson, PhD, past president of the supplement industry trade bunch Council for Mindful Nutrition, says in a news release that vitamins still have other imperative employments.
“These results do not of course refute other evidence of benefits for vitamin E and vitamin C for other conditions, including safe function, mental sharpness, and eye health. Buyers would be well advised to guarantee satisfactory immaterial of all basic nutrients through a great diet additionally use of a multivitamin, and chosen other supplements counting vitamins E and C, vitamin D, calcium, and EPA and DHA omega-3 fatty acids.”