May 21, 2003 — A medicate utilized for 50 a long time to battle bipolar clutter might ended up the most current Alzheimer’s treatment.
Modern ponders appear that lithium — at dosages comparable to those utilized to treat bipolar clutter — avoids Alzheimer’s illness in mice. A report on the tests, conducted at the College of Pennsylvania lab of Dwindle Klein, MD, PhD, shows up within the May 22 issue of the diary Nature.
Individuals with Alzheimer’s infection get a buildup of plaque outside nerve cells within the brain. They too get a buildup of fiber-like “tangles” interior brain cells. Lithium pieces an chemical — GSK-3 — pivotal to the improvement of both the plaque and the tangles.
“A restorative dosage of lithium uniquely diminishes” brain levels of plaque, Klein and colleagues report. Painkillers within the ibuprofen family — known as NSAIDs — battle plaque in a diverse way. “Combination treatment with lithium and NSAIDs may have an improved impact in decreasing [plaque],” the analysts recommend.
The thought is still exceptionally much test. In an article accompanying the Klein team’s report, two Alzheimer’s specialists caution that blocking the GSK-3 protein might have undesirable side impacts. One of these could be intestinal cancer, caution Bart De Strooper, MD, PhD, of Catholic College in Leuven, Belgium, and James Woodgett, PhD, of the College of Toronto in Ontario, Canada. Be that as it may, no connect has been found between intestinal cancer and lithium, which has been utilized for numerous a long time to treat bipolar clutter.
More youthful patients who take lithium ordinarily get over its side impacts. But these side impacts are more regrettable in elderly patients. And lithium can be a unsafe medicate. Fair a small bit as well much can harm the kidneys. For these reasons, the Klein group, De Strooper, and Woodgett recommend that it would be a great thought to create more secure GSK-3 inhibitors.
“GSK-3 inhibitors may well be an appealing expansion to the list of candidate drugs for anticipating [Alzheimer’s] plaques — with the potential advantage of hindering the arrangement of tangles, as well,” De Strooper and Woodgett type in.
SOURCE: Nature, May 22, 2003.