Common Cold Meds May Pose Health Threats Leave a comment

By Steven Reinberg

HealthDay Columnist

WEDNESDAY, March 19, 2014 (HealthDay News) — Over-the-counter sinus and torment remedies that combine two common fixings — phenylephrine and acetaminophen — might cause serious side effects such as high blood pressure, dizziness and tremors, Modern Zealand analysts warn.

These side effects happen because acetaminophen (the main ingredient in Tylenol) boosts the impacts of phenylephrine, according to a report within the Walk 20 issue of the New Britain Journal of Medication.

Items containing this drug combination incorporate Tylenol Sinus, Sudafed PE Sinus, Benadryl Sensitivity Additionally Sinus and Excedrin Sinus Migraine.

“What we found was astounding since it hasn’t been studied or detailed,” said lead researcher Hartley Atkinson, managing executive of Rearward Pharmaceuticals, Ltd., in Auckland.

Phenylephrine, which replaced pseudoephedrine in many over-the-counter drugs, relieves nasal clog from colds, allergies and feed fever. Pseudoephedrine had gotten to be a source for making the unlawful medicate methamphetamine, and the U.S. Nourishment and Sedate Administration asked producers to voluntarily evacuate it from their items.

When phenylephrine is combined with acetaminophen, blood levels of phenylephrine rise to four times higher than when the same sum of phenylephrine is utilized alone, Atkinson said.

“Fundamentally, if you allow the combination, a parcel more phenylephrine assimilates into your body than what you would be expecting,” Atkinson said.

Side impacts can moreover incorporate a sleeping disorder, migraine, heart palpitations, uneasiness and urine retention.

Atkinson famous that names on items containing phenylephrine warn of possible side impacts for people with heart illness or prostate issues. These warnings, be that as it may, allude as it were to the dose of phenylephrine approved for that product.

People with these conditions ought to know that in reality the measurements could be higher, he said.

Similar responses might occur with drugs such as vitamin C that are metabolized in the body like phenylephrine, Atkinson said.

“In a part of countries, there are drugs that contain acetaminophen, phenylephrine and vitamin C together, which seem cause an indeed greater interaction,” he said.

Atkinson stumbled upon this drug interaction while developing a new drug containing acetaminophen, ibuprofen (the main fixing in Advil) and phenylephrine. Ibuprofen does not cause harmful side impacts when combined with phenylephrine, he said.

This drug interaction is a problem administrative agencies have to be compelled to consider, Atkinson said.

Another master agreed the findings are worrisome.

“This article sheds light on a previously unknown response of acetaminophen with phenylephrine, which essentially raises the plausibility of an overdose with a single dosage,” said Dr. Houman Danesh, chief of integrative torment management at the Icahn School of Medicine at Mount Sinai, in New York City.

“Taking drugs which contain ibuprofen with phenylephrine may be safer with respects to phenylephrine poisonous quality,” Danesh said. “In any case, ibuprofen has increased dangers of stomach ulcers, kidney issues and hearts issues as well. So, once once more, counsel with your specialist.”

The FDA is mindful of the problem, but agency spokeswoman Andrea Fischer said it has constrained ability to direct.

“Both phenylephrine and pseudoephedrine are by and large recognized as secure and viable and may be showcased without premarket approval by the FDA,” Fischer said.

Likewise, it’s passable to combine either nasal decongestant with acetaminophen, she said.

Agreeing to McNeil Consumer Healthcare, the Johnson & Johnson subsidiary that produces a few of these dual-ingredient remedies, combination acetaminophen-phenylephrine drugs are safe.

“Based upon clinical ponders, years of utilize and post-marketing surveillance, we believe over-the-counter measurements of acetaminophen and phenylephrine, when taken together, are considered secure,” said Jodie Wertheim, a McNeil spokeswoman.

“When utilized as coordinated, over-the-counter solutions containing acetaminophen and phenylephrine are both viable and well-tolerated,” she added.

Not everybody is convinced, however.

“More caution should be handed-off to consumers,” said Victoria Richards, an associate professor of therapeutic sciences at the Frank H. Netter M.D. School of Pharmaceutical at Quinnipiac College in North Haven, Conn.

“Consumers should see at the names carefully and talk with the drug specialist or with their specialist to understand precisely what they’re taking,” she said.

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